ATLANTA (January 16, 2015) — Findings presented in a study titled “Compared to Sucrose, Previous Consumption of Fructose and Glucose Monosaccharides Reduces Survival and Fitness of Female Mice” by Ruff et al.1 should be interpreted with caution. The authors overstate that “This study provides unique experimental evidence that the consumption of a 1:1 ratio of F/G can dramatically decrease female mammalian health compared with the intake of an isocaloric amount of sucrose” as it is well-established that findings in one species are often different that those in other species. The study was conducted on mice and it is well known that humans and rodents metabolize substances differently. The authors report that female, but not male, mice eating fructose and glucose live less and reproduce less than mice fed sucrose. Unfortunately, no necropsy or physical exams including blood parameters and metabolic tests throughout the study were reported so any potential reason proposed for these findings would simply be speculation. As Dr. Luc Tappy, a researcher that focuses on environmental and dietary factors involved in the development of obesity and type 2 diabetes commented on this study, “There is presently no hint regarding the possible underlying mechanisms.”2