Mannitol

Mannitol is a polyol (sugar alcohol) widely used in the food and pharmaceutical industries because of its unique functional properties. It is about 50 percent as sweet as sucrose and has a desirable cooling effect often used to mask bitter tastes. Mannitol is non-cariogenic and has a low caloric content. Mannitol is suitable for ingestion and has been used safely around the world for over 60 years.

Mannitol is found in abundance in nature, particularly in exudates from trees, and in marine algae and fresh mushrooms. It is an isomer of sorbitol and is typically produced today by the hydrogenation of specialty glucose syrups. Mannitol is commercially available in variety of powder and granular forms. In the United States, mannitol is provided by a number of manufacturers, including Roquette America, and SPI Polyols.

Functional Advantages

Unlike sorbitol, a polyol often used for its humectant properties, mannitol is nonhygroscopic (does not pick up moisture). For this reason, it is often used as a dusting powder for chewing gum to prevent the gum from sticking to manufacturing equipment and wrappers. Due to its high melting point (165-169o C), mannitol is also used in chocolate-flavored coating agents for ice cream and confections. It has a pleasant taste, is very stable to moisture pickup and does not discolor at high temperatures, which makes mannitol ideal for use in pharmaceuticals and nutritional tablets.

Facts About Mannitol

  • Reduced-calorie sweetener with only 1.6 calories per gram
  • It is nonhygroscopic
  • Provides sweetness with a clean, cool pleasant taste
  • May be a useful alternative sweetener for people with diabetes
  • Does not contribute to the formation of dental caries.

 

Beneficial to People with Diabetes

The control of blood glucose, lipids and body weight are three major goals in diabetes management. Mannitol is slowly absorbed from the intestinal tract. Therefore, when mannitol is used, the rise in blood glucose and demand for insulin is much less than would be experienced after sucrose ingestion. The reduced caloric value of mannitol compared to sucrose (1.6 vs. 4.0 calories per gram) is consistent with the objective to control caloric intake and body weight in people with diabetes. Products sweetened with mannitol in place of sugar may be useful in providing a wider variety of reduced calorie and sugar-free choices to people with diabetes.

Recognizing that diabetes is complex and requirements for its management may vary between individuals, the usefulness of mannitol should be discussed between individuals and their health care providers. Foods sweetened with mannitol may contain other ingredients that also contribute calories and other nutrients. These must be considered in meal planning.

Does Not Promote Tooth Decay

Polyols, such as mannitol, are resistant to metabolism by oral bacteria and do not increase the acidity of the mouth after ingestion. This means that they will not lead to cavities or erode tooth enamel. The usefulness of polyols (including mannitol) as alternatives to sugars and as part of a comprehensive program including proper dental hygiene has been recognized by numerous authorities, including the American Dental Association. The Food and Drug Administration has approved the use of a "does not promote tooth decay" health claim in labeling for sugar-free foods that contain polyols, including mannitol.

How the Body Uses Mannitol

Mannitol, like all polyols, is a low digestible carbohydrate that is only partially absorbed from the small intestine and not metabolized. In the lower part of the intestinal tract, colonic bacteria metabolize some of the non-absorbed portion. In some people, this may occasionally cause softer stools or more intestinal gas than usual, similar to the effects of complex carbohydrate foods such as beans or prunes.

A person's response to low digestible carbohydrates varies depending on individual factors such as amount and frequency of consumption. The U.S. Food and Drug Administration's regulation for mannitol requires the following label statement for foods whose reasonably foreseeable consumption may result in the daily ingestion of 20 grams of mannitol: "Excess consumption may have a laxative effect." Mannitol is used in very small amounts in foods so the few people who may be sensitive usually have no problem if they gradually increase their consumption of low digestible carbohydrates.

Safety

The use of mannitol in food is broadly permitted by FDA food additive regulations (21 CFR 180.25). The Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives (JECFA) has reviewed the safety data and concluded that mannitol is safe. JECFA has allocated a temporary Acceptable Dietary Intake of 0-50mg/kg. Mannitol has monographs in the United States Pharmacopoeia/National Formulary (USP/NF), as well as the various pharmacopoeias around the world. Mannitol is included in the Food Chemical Codex (FCC).

Multiple Ingredient Approach to Calorie Control

Today, more than ever, Americans are recognizing that monitoring total caloric intake is essential to a healthy lifestyle. Calorie-controlled foods facilitate reaching today's nutrition and health goals. Good taste remains a vital factor in consumer acceptance of these products.

Mannitol works well with other ingredients and may be synergistic with other sweeteners. The combination of sweeteners is often sweeter and better tasting than individual sweeteners. These blends provide taste, economic, and stability advantages.

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References

American Dental Association. Position Statement on the Role of Sugar-Free Foods and Medications in Maintaining Good Oral Health. Adopted October 1998.

Dills, W. Sugar alcohols as bulk sweeteners. Ann Rev Nutr. 1989; 9:161-186.

Federation of American Societies for Experimental Biology. The evaluation of the energy of certain polyols used as food ingredients. June 1994.

Joint FAO/WHO Expert Committee on Food Additives. Toxicological evaluation of certain food additives: mannitol. Twenty-ninth report. WHO Technical Report Series 733, p. 35. Geneva, 1982.

Le, A.S. & Mulderrig, K.B. Sorbitol and Mannitol. In: Alternative Sweeteners, Third Edition. L.O. Nabors, ed., Marcel Dekker, Inc., New York, 2001.

Office of the Federal Register, General Services Administration, Code of Federal Regulations, Title 21, Section 101.80, Health Claims: dietary sugar alcohols and dental caries. Washington, D.C., U.S. Government Printing Office, 1999.

Office of the Federal Register, General Services Administration. Code of Federal Regulations, Title 21, Section 180.25. Mannitol. Washington, DC, US Government Printing Office, 1999.

Senti FR. Health Aspects of Sugar Alcohols and Lactose. Bethesda, MD: Federation of American Societies for Experimental Biology; 1986:85.

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